In this passage, Paul prays for us to "know" God - not just know about God. Why does he pray for this? A: We drift from being enchanted with God to being mechanical and cold. Having a high view of self, and a low view of God, we need the Holy Spirit to give us sight of Jesus and awaken our affections for Him.
Coram Deo simply means "face-to-face" with God. It's the posture we live where we are (1) in the presence of God, (2) under the authority of God, and (3) to the glory of God. Paul, in his letter to the greater church in metro Ephesus, helps us see not only the power of God's gospel to change us from the inside out, but also how that plays out in our lives as husbands, wives, employees, etc... Paul helps us see Coram Deo living as we are in Christ.